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Accreditation/Credit Designation Physicians’ Education Resource ®, LLC, is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Physicians’ Education Resource ®, LLC, designates this enduring material for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Acknowledgment of Commercial Support This activity is supported by an educational grant from AstraZeneca. Release Date: October 31, 2017 Expiration Date: October 31, 2018 Media: Internet - based Activity Overview This Clinical Interchange™ features an expert panel discussion of noteworthy clinical data on immune checkpoint inhibitors. Practice-changing data and emerging immunotherapeutic strategies for cancers of the lung, head and neck, and bladder are summarized, along with expert discussions on the clinical application of these data and the evolving landscape of selective biomarkers. This program also includes a case-based discussion on the management of immune-related adverse events.

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Acknowledgment of Commercial Support This activity is supported by an educational grant from AstraZeneca. CME Activity Table of Contents • Introduction and Background of Immunotherapy • Segment 1: Evolving Treatment Paradigms With the Use of Immuno-Oncology Strategies for the Management of Non–Small Cell Lung Cancer • Segment 2: Clinical Applications of Immuno-Oncology in the Multimodal Management of Head and Neck Squamous Cell Carcinoma • Segment 3: How Immuno-Oncology Strategies Are Changing Treatment Paradigms in Bladder Cancer • Segment 4: What Have We Learned About the Biomarkers and Resistance? • Segment 5: Case-Based Panel Discussion: Managing Patients and Toxicities/Closing Remarks Instructions for This Activity and Receiving Credit • You will need to login to participate in the activity. • Each presentation may contain an interactive question(s). You may move forward through the presentation; however, you may not go back to change answers or review videos/content until you finish the presentation. • At the end of the activity, “educational content/video files” will be available for your reference.

• In order to receive a CMEcertificate, participants must complete the activity. • Complete the posttest and pass with a score of 70% or higher, complete the evaluation and then click on request for credit. Programma kognitivnoj reabilitacii. Participants may immediately download a CME certificate upon completion of these steps. Target Audience This educational activity is directed toward medical oncologists and fellows who treat patients with cancer. Nurse practitioners, nurses, physician assistants, pharmacists, researchers, and other healthcare professionals are also invited to participate.